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	Provedor de dados BJID (1) Genet. Mol. Biol. (1) Autor Zaccariotto,Tânia Regina (2) Alves,Paulo César Martins (1) Arrym,Mauro Pedromonico (1) Castelhano,Mariana Virginello (1) Guimarães,Fernando (1) Lemos,Renata Muller Banzato Pinto de (1) Levy,Carlos Emilio (1) Mazzola,Taís Nitsch (1) Silva,Marcos Tadeu Nolasco da (1) Sonati,Maria de Fátima (1) Wobeto,Vânia Peretti de Albuquerque (1) Mais... Palavra-chave BCG (1) Citotoxicity (1) Genetic polymorphisms (1) HIV/Aids (1) Haptoglobin (1) Hemoglobin (1) Immunologic (1) Tuberculosis (1) Youth (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2019 (1) 2008 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Polymorphism of human haptoglobin and its clinical importance Genet. Mol. Biol. Wobeto,Vânia Peretti de Albuquerque; Zaccariotto,Tânia Regina; Sonati,Maria de Fátima. Haptoglobin (Hp) is a plasma glycoprotein, the main biological function of which is to bind free hemoglobin (Hb) and prevent the loss of iron and subsequent kidney damage following intravascular hemolysis. Haptoglobin is also a positive acute-phase protein with immunomodulatory properties. In humans, the HP locus is polymorphic, with two codominant alleles (HP1 and HP2) that yield three distinct genotypes/phenotypes (Hp1-1, Hp2-1 and Hp2-2). The corresponding proteins have structural and functional differences that may influence the susceptibility and/or outcome in several diseases. This article summarizes the available data on the structure and functions of Hp and the possible effects of Hp polymorphism in a number of important human disorders. Tipo: Info:eu-repo/semantics/article Palavras-chave: Haptoglobin; Hemoglobin; Genetic polymorphisms. Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000400002 Preservation of cytotoxic granule production in response to mycobacterial antigens by T-lymphocytes from vertically HIV-infected Brazilian youth on effective combined antiretroviral therapy BJID Arrym,Mauro Pedromonico; Alves,Paulo César Martins; Castelhano,Mariana Virginello; Mazzola,Taís Nitsch; Lemos,Renata Muller Banzato Pinto de; Zaccariotto,Tânia Regina; Levy,Carlos Emilio; Guimarães,Fernando; Silva,Marcos Tadeu Nolasco da. ABSTRACT Background: HIV infection harms adaptive cellular immunity mechanisms. Long-term virological control by combined antiretroviral therapy (cART) reduces the risk of mycobacterial infections. Thus, we aimed to study cellular responses to mycobacterial antigens in 20 HIV-infected adolescents with at least one year of virological control (HIV-RNA <40 copies/mL) and 20 healthy adolescents. Methods: We evaluated CD8 and γδ T-cell degranulation by measurement of CD107a membrane expression after stimulation with lysates from BCG (10 µg/mL) and H37RA Mycobacterium tuberculosis (Mtb, 10 µg/mL). Immune activation and antigen-presenting ability were also assessed by determination of HLA-DR, CD80, and CD86 markers. Results: TCR γδ T-cell CD107a expression... Tipo: Info:eu-repo/semantics/article Palavras-chave: HIV/Aids; BCG; Youth; Tuberculosis; Citotoxicity; Immunologic. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000300151 Registros recuperados: 2 Primeira ... 1 ... Última

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